Study of the glioblastoma microenvironment and its involvement in chemoresistance using biomimetic microfluidic chips

This page displays information about the project BIO2016-79092-R, funded by the Spanish Ministry of Education and Science. Scientific leader of the project: Ignacio Ochoa Garrido



Ignacio Ochoa Garrido

Jorge Alfaro Torres

Maria Isabel Marquina Ibañez

Ana Herrero Ibañez

David Rivero Celada


  •  Study of the tumor microenvironment and assess their potential use as prognosis agents in the evolution of the disease.
  • Inprovement of an in vitro model that allows us to simulate the complex tumor interactions with its microenvironment.
  • Determine, using microfluidic devices, the role of the microenvironment in chemoresistance to drugs currently approved in the clinic (Temozolomide).
  • Correlate the data obtained in patients with the results of biomimetic models to validate its use as a predictive tool of tumor behavior. Satisfactory achievement of this project will be an important achievemet in the investigation of this tumor type. Technology developed in this project will significantly reduce time and cost of developing new drugs. It is a tool that, along with primary cell culture, can get closer the goal of the personalized therapies for this and other tumor types. In addition, intensive use of microfluidic devices will minimize the use of animal testing and reduce the related ethical problems. Last but not least, development of such technologies can boost the national biotechnology sector with the establishment of companies in the field of microfluidics and microtechnology.