The AMB group has a wide experience in the development of constitutive laws for vascular and cardiac tissue. Currently our research lines are focused on simulating multiphysics and multiscale phenomena. We have developed advanced constitutive laws to reproduce inelastic effects on soft tissue that incorporates microstructural information, which determine the macroscopic performance of the tissue. The experimental tests performed in our tissue characterization laboratory allow fitting and validating the developed models. Interactions of the tissue with biomaterials or medical devices have been also studied. We have important collaboration with clinical partners in hospitals to apply our research in problems with special clinical interest.
The main research lines:
- Multiphysics and multiscale modelling of cardiovascular tissue
- Medical devices: stents and vena cava filters
- Biomechanics and mechanobiology of the atheroma plaque
- Growth, remodelling and damage of cardiovascular tissue
- Mechanical characterization of cardiovascular tissue
Some recent projects:
- In silico-in vitro framework for the analysis of atherosclerotic plaque evolution and vulnerability. AteroGrowMod. 2020-2023
- Computational biomechanics and bioengineering 3D printing to develop a personalised regenerative biological ventricular assist device to provide lasting functional support to damaged hearts. BRAVꓱ. European Union´s Horizon 2020. Grant agreement 874827. 2020-2024
- In silico-in vitro tools to improve drug-eluting intravascular devices. LMP121-18. 2018-2020
- In silico-in vitro analysis of atheroma plaque formation and development. AtheroMech. 2017-2020
- Prediction of drug diffusion on complex biomimetic environment. DrugDiff. 2016-2017
- Patient-Specific Modelling of the Aortic valve replacement: Advance towards a Decision Support System. DessValve. 2016-2017
- Numerical analysis and optimization of drug-eluting intravascular devices. Application to stents and balloons design for treating atherosclerosis. InVasFar-DiMe. 2014-2016
- Patient-Specific image-based computational flow dynamic simulations for assessment of optimal biological aortic Valve replacement selection and delivery. PsValve. 2014-2015
- Modelling and Simulation of Ageing and Atherosclerosis in Arteries. AgeAthero. 2012-2013
- Development of a computational tool for the study of fluid-solid interactions problems in a cardiovascular framework. Application to the design of a new prototype of antithrombotic filter for vena cava. Filde-FSI. 2011-2013
- Design and development of a new prototype of an intravascular device (stent) with variable radial force for stenotic lesions of carotid arteries. VaradFor-Stent. 2010-2012
